Efficiency parameters in artificial allosteric systems-Reference-Cited by-同舟云学术

Efficiency parameters in artificial allosteric systems

Published:2016 Issue:34 Volume:14 Page:7994-8001
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Schneider Hans-Jörg¹²³⁴

Affiliation:

1. FR Organische Chemie

2. Universität des Saarlandes

3. D 66041 Saarbrücken

4. Germany

Abstract

It is shown that the conformational energy ΔG_C required for the formation of a suitable cavity or cleft for ligand binding in absence of an effector E is the essential factor for the efficiency of synthetic allosteric systems with positive cooperativity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01303A

Reference88 articles.

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