Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents-Reference-Cited by-同舟云学术

Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents

Published:2021 Issue:1 Volume:12 Page:120-128
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Fernández de Luco Julia¹²³⁴⁵^ORCID,Recio-Balsells Alejandro I.¹²³⁴⁵^ORCID,Ghiano Diego G.¹²³⁴⁵,Bortolotti Ana⁶⁷⁸⁴⁵,Belardinelli Juán Manuel⁶⁷⁸⁴⁵,Liu Nina⁹¹⁰¹¹¹²¹³,Hoffmann Pascal¹⁴¹⁵¹⁶¹⁷¹⁸,Lherbet Christian¹⁴¹⁵¹⁶¹⁷¹⁸,Tonge Peter J.⁹¹⁰¹¹¹²¹³^ORCID,Tekwani Babu¹⁹²⁰²¹¹³,Morbidoni Héctor R.⁶⁷⁸⁴⁵^ORCID,Labadie Guillermo R.¹²³⁴⁵^ORCID

Affiliation:

1. Instituto de Química Rosario

2. UNR

3. CONICET

4. Rosario

5. Argentina

6. Laboratorio de Microbiología Molecular

7. Facultad de Ciencias Médicas

8. Universidad Nacional de Rosario

9. Department of Chemistry

10. Institute of Chemical Biology & Drug Discovery

11. Stony Brook University

12. Stony Brook

13. USA

14. LSPCMIB

15. UMR-CNRS 5068

16. Université Paul Sabatier-Toulouse III

17. 31062 Toulouse Cedex 9

18. France

19. National Center for Natural Products Research & Department of Biomolecular Sciences

20. School of Pharmacy

21. University of Mississippi

Abstract

A collection of 37 triazolyl-triclosan derivatives were prepared as possible antileishmanial drugs. The InhA ortholog in Leishmania donovani was proposed as a putative druggable target.

Funder

Fondo para la Investigación Científica y Tecnológica

UK Research and Innovation

Universidad Nacional de Rosario

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Promoción Científica y Tecnológica

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link