Multifunctional organometallic compounds for the treatment of Chagas disease: Re(<scp>i</scp>) tricarbonyl compounds with two different bioactive ligands-Reference-Cited by-同舟云学术

Multifunctional organometallic compounds for the treatment of Chagas disease: Re(i) tricarbonyl compounds with two different bioactive ligands

Published:2023 Issue:6 Volume:52 Page:1623-1641
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Soba Mariano¹²^ORCID,Scalese Gonzalo¹^ORCID,Casuriaga Federico¹,Pérez Nicolás¹^ORCID,Veiga Nicolás¹^ORCID,Echeverría Gustavo A.³^ORCID,Piro Oscar E.³^ORCID,Faccio Ricardo⁴^ORCID,Pérez-Díaz Leticia⁵^ORCID,Gasser Gilles⁶^ORCID,Machado Ignacio⁷^ORCID,Gambino Dinorah¹^ORCID

Affiliation:

1. Área Química Inorgánica, DEC, Facultad de Química, Universidad de la República, Uruguay

2. Programa de Posgrado en Química, Facultad de Química, Universidad de la República, Montevideo, Uruguay

3. Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata and Institute IFLP (CONICET, CCT-La Plata), La Plata, Argentina

4. Área Física, DETEMA, Facultad de Química, Universidad de la República, Uruguay

5. Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Uruguay

6. Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, France

7. Área Química Analítica, DEC, Facultad de Química, Universidad de la República, Uruguay

Abstract

Multifunctional Re(i) tricarbonyls including phenanthroline derivatives and Clotrimazole showed high activity against Trypanosoma cruzi and inhibited parasite lanosterol 14-α-demethylase (CYP51).

Funder

Agencia Nacional de Investigación e Innovación

Consejo Nacional de Investigaciones Científicas y Técnicas

European Research Council

Agence Nationale de la Recherche

Universidad Nacional de La Plata

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D2DT03869B

Reference96 articles.

1. Reactivation of Chagas Disease: Implications for Global Health

2. Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

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4. Challenges in Chagas Disease Drug Discovery: A Review

5. World Health Organization Why are some tropical diseases called ‘neglected’? , 2021 , https://www.who.int/news-room/questions-and-answers/item/neglected-tropical-diseases , visited 2022

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