New small-molecule alcohol synthesis by breaking the space limitation of the “aromatic cage” in <i>Pseudomonas</i> sp. AK1 BBOX-Reference-Cited by-同舟云学术

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New small-molecule alcohol synthesis by breaking the space limitation of the “aromatic cage” in Pseudomonas sp. AK1 BBOX

Published:2023 Issue:31 Volume:21 Page:6397-6404
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xu Zhiqin¹,Mo Yaling¹,Li Zhengwen¹,Ban Shurong¹,Song Heng²³^ORCID

Affiliation:

1. School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi Province 030001, China

2. College of Chemistry & Molecular Science, Wuhan University, Wuhan, Hubei Province 430072, China

3. Wuhan University Shenzhen Research Institute, Shenzhen, Guangdong Province 518000, China

Abstract

The hydroxylation of cyclic quaternary ammonium analogues were significantly improved by semi-rational design of the “aromatic cage” amino acid in Pseudomonas sp. AK1 BBOX.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00830D

Reference31 articles.

1. Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

2. 2-Oxoglutarate-Dependent Oxygenases

3. The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism (1967 to 1999)

4. The biosynthesis of penicillins and cephalosporins

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