Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients – comparison of two sampling methods

Author:

van Oort Pouline M. P.1234,White Iain R.56789,Ahmed Waqar567810,Johnson Craig5678,Bannard-Smith Jonathan111278,Felton Timothy11127810,Bos Lieuwe D.1234,Goodacre Royston1314158ORCID,Dark Paul11127810,Fowler Stephen J.11127810ORCID

Affiliation:

1. Department of Intensive Care

2. Amsterdam UMC – location Academic Medical Centre (AMC)

3. Amsterdam

4. the Netherlands

5. Manchester Institute of Biotechnology

6. University of Manchester

7. Manchester

8. UK

9. Laboratory for Environmental and Life Sciences

10. Division of Infection

11. Manchester Academic Health Science Centre

12. Manchester University Hospitals NHS Foundation Trust

13. Department of Biochemistry

14. Institute of Integrative Biology

15. University of Liverpool

Abstract

Exhaled breath analysis is a promising new diagnostic tool, but currently no standardised method for sampling is available in mechanically ventilated patients. We identified potential sources of bias as illustrated in this figure.

Funder

National Institute for Health Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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