The antibacterial activity of p-tert-butylcalix[6]arene and its effect on a membrane model: molecular dynamics and Langmuir film studies

Author:

Wrobel Ellen C.12345ORCID,de Lara Lucas S.62375ORCID,do Carmo Taiza A. S.89105,Castellen Patrícia12345ORCID,Lazzarotto Márcio1112135ORCID,de Lázaro Sérgio R.12345ORCID,Camilo Alexandre62375ORCID,Caseli Luciano141516175ORCID,Schmidt Rolf18192021,DeWolf Christine E.18192021ORCID,Wohnrath Karen12345ORCID

Affiliation:

1. Department of Chemistry

2. Universidade Estadual de Ponta Grossa

3. Ponta Grossa

4. Par84030-900

5. Brazil

6. Department of Physics

7. Paraná 84030-900

8. Academic Department of Mathematic

9. Universidade Federal Tecnológica do Paraná – Campus Ponta Grossa

10. Paraná 84016-210

11. Department of Organic Chemistry

12. Universidade Federal do Rio Grande do Sul

13. Rio Grande do Sul 91501-970

14. Instituto de Ciências Ambientais

15. Químicas e Farmacêuticas

16. Universidade Federal de São Paulo

17. São Paulo (SP) 09972-970

18. Department of Chemistry and Biochemistry and Concordia Centre for NanoScience Research

19. Concordia University

20. Montreal

21. Canada

Abstract

Expulsion of p-tert-butylcalix[6]arene molecules from a monolayer in a biologically relevant pressure regime, π = 30 mN m−1, correlates with their lack of antibacterial activity.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Instituto Nacional de Ciência e Tecnologia em Eletrônica Orgânica

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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