Michael addition-driven synthesis of cytotoxic palladium(<scp>ii</scp>) complexes from chromone thiosemicarbazones: investigation of anticancer activity through <i>in vitro</i> and <i>in vivo</i> studies-Reference-Cited by-同舟云学术

Michael addition-driven synthesis of cytotoxic palladium(ii) complexes from chromone thiosemicarbazones: investigation of anticancer activity through in vitro and in vivo studies

Published:2023 Issue:33 Volume:47 Page:15748-15759
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Haribabu Jebiti¹^ORCID,Balakrishnan Nithya²,Swaminathan Srividya³,Dorairaj Dorothy Priyanka²^ORCID,Azam Mohammad⁴,Subarkhan Mohamed Kasim Mohamed⁵^ORCID,Chang Yu-Lun⁶^ORCID,Hsu Sodio C. N.⁶⁷^ORCID,Štarha Pavel⁸^ORCID,Karvembu Ramasamy²^ORCID

Affiliation:

1. Facultad de Medicina, Universidad de Atacama, Los Carreras 1579, 1532502 Copiapo, Chile

2. Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, India

3. Center for Computational Modeling, Chennai Institute of Technology (CIT), Chennai 600069, India

4. Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

5. The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, P. R. China

6. Department of Medicinal and Applied Chemistry, Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

7. Department of Medical Research, Kaohsiung Medical University Hospital; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

8. Department of Inorganic Chemistry, Faculty of Science, Palacky University Olomouc, 17 Listopadu 12, 77146 Olomouc, Czech Republic

Abstract

Michael addition derived Pd(ii) complexes exhibited potential anticancer activity in HeLa cells via apoptosis. In vivo models showed that the complexes did not cause any harm to the treated mice, portraying better selectivity than cisplatin.

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ02067C

Reference54 articles.

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