Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides-Reference-Cited by-同舟云学术

Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides

Published:2019 Issue:1 Volume:21 Page:157-163
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Wang Dong¹²³⁴⁵^ORCID,Liu Zhenlin¹²³⁴⁵,Wang Zhentao¹²³⁴⁵,Ma Xinyue¹²³⁴⁵,Yu Peng¹²³⁴⁵

Affiliation:

1. China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry

2. College of Biotechnology

3. Tianjin University of Science and Technology

4. Tianjin 300457

5. China

Abstract

Metal- and base-free thiolation of the unactivated methyl C(sp³)–H bond in 2-picoline N-oxides with thiols is achieved by a one-pot, two-step sequence, including a TFAA-mediated [3,3]-sigmatropic rearrangement of pyridine N-oxides and TBAB-catalyzed direct conversion of trifluoroacetates into thioethers.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/GC/C8GC03072C

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