A ratiometric fluorescence probe for selective and sensitive detection of leucine aminopeptidase in lysosome-Reference-Cited by-同舟云学术

A ratiometric fluorescence probe for selective and sensitive detection of leucine aminopeptidase in lysosome

Published:2022 Issue:60 Volume:58 Page:8364-8367
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yuan Di¹,Xu Ziwei¹,Zhang Bingling¹,Yin Xiong¹^ORCID,Ye Jiqing²,Zhou Xiaole¹^ORCID,Wang Leyu¹^ORCID

Affiliation:

1. State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China

2. State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China

Abstract

A high-performance ratiometric probe P1-Leu was developed based on a D–A–D fluorophore for the detection of LAP level in lysosome. P1-Leu has low detection limit and broad linear range due to the low background oriented from its structure.

Funder

National Natural Science Foundation of China

Central University Basic Research Fund of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC02214A

Reference42 articles.

1. Dye-Doped Fluorescent Silica Nanoparticles for Live Cell and In Vivo Bioimaging

2. Near-Infrared-II Bioimaging for in Vivo Quantitative Analysis

3. Real-time imaging of viscosity in the mitochondrial matrix by a red-emissive molecular rotor

4. Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain

5. Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Monitoring cysteine changes and assessing ferroptosis in diabetic mice with a lysosome-targeted near-infrared fluorescence probe;Sensors and Actuators B: Chemical;2024-12

2. Visualizing lysosomes hypochlorous acid in Parkinson's disease models by a novel fluorescent probe;Talanta;2024-11

3. A lysosomal-targeted and viscosity-ultrasensitive near-infrared fluorescent probe for sensing viscosity in cells and a diabetic mice model;Talanta;2024-10

4. Activatable Fluorescence and Bio/Chemiluminescence Probes for Aminopeptidases: From Design to Biomedical Applications;Advanced Materials;2024-09-05

5. D-A-D type based NIR fluorescence probe for monitoring the cysteine levels in pancreatic cancer cell during ferroptosis;Bioorganic Chemistry;2024-05