Iodine-catalyzed oxidative annulation: facile synthesis of pyrazolooxepinopyrazolones <i>via</i> methyl azaarene sp<sup>3</sup> C–H functionalization-Reference-Cited by-同舟云学术

Iodine-catalyzed oxidative annulation: facile synthesis of pyrazolooxepinopyrazolones via methyl azaarene sp³ C–H functionalization

Published:2022 Issue:6 Volume:20 Page:1236-1242
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang Xin-Ke¹,Miao Xiao-Yu¹,Zhou Yu¹,Wang Yu-Mei¹,Song Ying-Chun¹,Liu Hang¹,Xiong Yi-Lu¹,Li Ling-Yu¹,Wu An-Xin²^ORCID,Zhu Yan-Ping¹^ORCID

Affiliation:

1. School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Shandong, Yantai, 264005, P. R. China

2. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan, 430079, P. R. China

Abstract

An iodine-catalyzed methyl azaarene sp3 C–H functionalization has been developed for the synthesis of pyrazolooxepinopyrazolones. This method has wide range of substrates, low catalyst loading, good functional group tolerance and metal-free conditions.

Funder

National Natural Science Foundation of China

Yantai Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02436A

Reference62 articles.

1. J. J.Vaquero , A. M.Cuadro and B.Herradón , Modern Heterocyclic Chemistry , Wiley-VCH , Weinheim , 2011 , pp. 1865–1988

2. G.Dyker , Handbook of C−H Transformations Applications in Organic Synthesis , Wiley-VCH , Weinheim , 2005