Switching from <i>gem</i>-difluorovinylation to carboxylation: ligand-enabled palladium-catalyzed Heck annulation of alkene-tethered aryl halides with sodium difluorochloroacetate-Reference-Cited by-同舟云学术

Switching from gem-difluorovinylation to carboxylation: ligand-enabled palladium-catalyzed Heck annulation of alkene-tethered aryl halides with sodium difluorochloroacetate

Published:2024 Issue:12 Volume:11 Page:3491-3496
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xia Yu¹^ORCID,Li Wenqi¹,Wei Minzhu¹,Zhang Yonghong¹^ORCID,Wang Bin¹^ORCID,Wu Shaofeng¹,Liu Chenjiang¹^ORCID

Affiliation:

1. Urumqi Key Laboratory of Green Catalysis and Synthesis Technology, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education & Xinjiang Uygur Autonomous Region, State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi 830017, P. R. China

Abstract

The use of a ligand to tune palladium-catalyzed intramolecular Heck gem-difluorovinylation and carboxylation is reported. Sodium difluorochloroacetate (ClCF2COONa) acts as both a difluorocarbene (:CF2) and carboxyl source.

Funder

National Natural Science Foundation of China

International Science and Technology Cooperation Programme

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00392F

Reference45 articles.

1. Mapping the Melatonin Receptor. 6. Melatonin Agonists and Antagonists Derived from 6H-Isoindolo[2,1-a]indoles, 5,6-Dihydroindolo[2,1-a]isoquinolines, and 6,7-Dihydro-5H-benzo[c]azepino[2,1-a]indoles

2. Inhibition of Tubulin Polymerization by 5,6-Dihydroindolo[2,1-a]isoquinoline Derivatives

3. Indolo[2,1-a]isoquinolines. Syntheses, steroid hormone receptor binding affinities, and cytostatic activity

4. C-12-Substituted Indolo[2,1-a]Isoquinolines as Estrogen Receptor Affinic Cytostatic Agents

5. (-)-Cryptaustoline: its synthesis, revision of absolute stereochemistry, and mechanism of inversion of stereochemistry