Cell-SELEX and application research of a DNA aptamer against esophageal squamous cell carcinoma (ESCC) cell line TE-1

Author:

Jin Baijiang1ORCID,Yang Gaojian1,Guo Zhukang12,Chen Zhu32,Liu Yuan34,Li Song34,Chen Hui34,Fang Yile12,Deng Yan34,He Nongyue15ORCID

Affiliation:

1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

2. Department of Clinical Laboratory, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

3. School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

4. Institute for Future Sciences, University of South China, Changsha, Hunan 410000, China

5. Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, Hunan, China

Abstract

This work reports a DNA aptamer selected with the cell-SELEX method, which specifically binds to esophageal cancer cell line TE-1 with great affinity and specificity both in vitro and in vivo.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

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