Validated liquid chromatography tandem mass spectrometry for simultaneous quantification of foretinib and lapatinib, and application to metabolic stability investigation-Reference-Cited by-同舟云学术

Validated liquid chromatography tandem mass spectrometry for simultaneous quantification of foretinib and lapatinib, and application to metabolic stability investigation

Published:2019 Issue:34 Volume:9 Page:19325-19332
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Alanazi Mohammed M.¹²³⁴⁵,Alkahtani Hamad M.¹²³⁴⁵^ORCID,Almehizia Abdulrahman A.¹²³⁴⁵^ORCID,Attwa Mohamed W.¹²³⁴⁵^ORCID,Bakheit Ahmed H.¹²³⁴⁵,Darwish Hany W.¹²³⁴⁵

Affiliation:

1. Department of Pharmaceutical Chemistry

2. College of Pharmacy

3. King Saud University

4. Riyadh

5. Saudi Arabia

Abstract

Foretinib metabolic rate is decreased in combination with lapatinib. Lapatinib metabolic rate is greatly increased in combination with foretinib. Dose recalculation should be considered when foretinib and lapatinib are used in combination.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA03251G

Reference22 articles.

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