Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)-Reference-Cited by-同舟云学术

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Published:2023 Issue:14 Volume:14 Page:3752-3762
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Thoreau Fabien¹^ORCID,Rochet Léa N. C.¹,Baker James R.¹^ORCID,Chudasama Vijay¹^ORCID

Affiliation:

1. Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK

Abstract

Using a bis-pyridazinedione-based disulfide rebridging agent, we enable the formation of various mAb, Fab′ and Fc conjugates with the ability to tune payload loading on each construct.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC06318B

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1. Antibody–Drug Conjugates: A Comprehensive Review

2. An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy

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