Component analysis and anti-pulmonary fibrosis effects of Rosa sterilis juice

Author:

Wang Liqun1ORCID,Li Yali12,Xia Rui1,Zheng Xinyue3,Li Xingjie1,Wu Shouxun1,Zhang Qianyu14,Li Sha1,Deng Yuanle1,Yao Yuqin1ORCID,Ye Tinghong3ORCID,Yin Wenya1

Affiliation:

1. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan, China

2. Prenatal Diagnosis Center, The Third Affiliated Hospital of Zhengzhou University – Maternal and Child Health Hospital of Henan Province, Zhengzhou 450052, China

3. Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China

4. Chongqing Academy of Metrology and Quality Inspection, Chongqing, 401121, China

Abstract

High levels of flavonoids, polyphenols, and vitamin C may be the functional components of RSJ, and RSJ exerts anti-pulmonary fibrosis effects by reducing inflammation and inhibiting EMT and fibroblast differentiation through the Smad2/3 pathway.

Funder

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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