Exploring a cascade Heck–Suzuki reaction based route to kinase inhibitors using design of experiments-Reference-Cited by-同舟云学术

Exploring a cascade Heck–Suzuki reaction based route to kinase inhibitors using design of experiments

Published:2015 Issue:11 Volume:13 Page:3382-3392
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ekebergh Andreas¹²³⁴,Lingblom Christine⁵⁶⁷⁸⁴,Sandin Peter¹²³⁴,Wennerås Christine⁵⁶⁷⁸⁴,Mårtensson Jerker¹²³⁴

Affiliation:

1. Department of Chemical and Biological Engineering

2. Chalmers University of Technology

3. SE-412 96 Gothenburg

4. Sweden

5. Department of Infectious Diseases

6. Sahlgrenska Academy

7. University of Gothenburg

8. SE-413 45 Gothenburg

Abstract

A fused tricyclic system with kinase inhibiting properties was assembledviaa palladium catalyzed tandem reaction. The reaction was optimized using statistical experimental design.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02694B

Reference45 articles.

1. Melanoma epidemiology and trends

2. Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma

3. Management of Cutaneous Melanoma

4. Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

5. Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

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