Towards99mTc-based imaging agents with effective doxorubicin mimetics: a molecular and cellular study
Author:
Affiliation:
1. Department of Chemistry
2. University of Zurich
3. CH-8057 Zurich
4. Switzerland
5. Institute of Molecular Cancer Research
6. Centro de Ciências e Tecnologias Nucleares
7. Universidade de Lisboa
8. PT-2695-066 Bobadela LRS
9. Portugal
Abstract
99mTc and Re conjugates of Doxorubicin accumulate in the nucleus, bind tightly to DNA and retain hTopoII inhibition.
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT00871B
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