Highly active antibacterial ferrocenoylated or ruthenocenoylated Arg-Trp peptides can be discovered by anl-to-dsubstitution scan-Reference-Cited by-同舟云学术

Highly active antibacterial ferrocenoylated or ruthenocenoylated Arg-Trp peptides can be discovered by anl-to-dsubstitution scan

Published:2014 Issue:11 Volume:5 Page:4453-4459
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Albada H. Bauke¹²³⁴,Prochnow Pascal⁵⁶³⁴,Bobersky Sandra¹²³⁴,Bandow Julia E.⁵⁶³⁴,Metzler-Nolte Nils¹²³⁴

Affiliation:

1. Inorganic Chemistry I – Bioinorganic Chemistry

2. Faculty of Chemistry and Biochemistry

3. Ruhr University Bochum

4. Bochum, Germany

5. Applied Microbiology

6. Faculty for Biology and Biotechnology

Abstract

By taking a systematic approach several short organometallic AMP conjugates were discovered which have very low hemolytic activity but virtually the same antimicrobial activity against MRSA as that of vancomycin.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC01822B

Reference39 articles.

1. Antimicrobial peptides of multicellular organisms

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4. Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies, ed. G. Wang, CABI, Wallingford, England, 2010. See also

5. Antimicrobial peptides: Clinical relevance and therapeutic implications

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