Intramolecular rhodium-catalysed [2 + 2 + 2] cycloaddition of linear chiral <i>N</i>-bridged triynes: straightforward access to fused tetrahydroisoquinoline core-Reference-Cited by-同舟云学术

Intramolecular rhodium-catalysed [2 + 2 + 2] cycloaddition of linear chiral N-bridged triynes: straightforward access to fused tetrahydroisoquinoline core

Published:2022 Issue:12 Volume:20 Page:2433-2445
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Llobat Alberto¹,Escorihuela Jorge¹^ORCID,Ramírez de Arellano Carmen¹^ORCID,Fustero Santos¹^ORCID,Medio-Simón Mercedes¹^ORCID

Affiliation:

1. Departamento de Química Orgánica, Universitat de València, Avda. Vicent Andrés Estellés s/n, Burjassot, 46100 Valencia, Spain

Abstract

Rhodium-catalyzed intramolecular [2 + 2 + 2] cycloaddition of linear chiral triynes having 4-atom tethers leads to, in a single step, complex tetrahydroisoquinolines having central chirality.

Funder

Ministerio de Ciencia, Innovación y Universidades

Agencia Estatal de Investigación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00340F

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1. The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

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3. Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection

4. Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

5. Copper Catalyzed One-Pot Three-Component Imination–Alkynylation–aza-Michael Sequence: Enantio- and Diastereoselective Syntheses of 1,3-Disubstituted Isoindolines and Tetrahydroisoquinolines

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