Chlorinated cobalt alkyne complexes derived from acetylsalicylic acid as new specific antitumor agents-Reference-Cited by-同舟云学术

Chlorinated cobalt alkyne complexes derived from acetylsalicylic acid as new specific antitumor agents

Published:2018 Issue:12 Volume:47 Page:4341-4351
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Obermoser Victoria¹²³⁴⁵,Baecker Daniel¹²³⁴⁵,Schuster Carina¹²³⁴⁵,Braun Valentin¹²³⁴⁵,Kircher Brigitte⁶⁷⁸⁹¹⁰,Gust Ronald¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Institute of Pharmacy

3. Center for Molecular Biosciences Innsbruck

4. University of Innsbruck

5. CCB – Centrum for Chemistry and Biomedicine

6. Immunobiology and Stem Cell Laboratory

7. Department of Internal Medicine V (Hematology and Oncology)

8. Innsbruck Medical University

9. 6020 Innsbruck

10. Austria

Abstract

Chlorine-substituted [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl complexes are selective COX-2 inhibitors with growth-inhibitory potential against COX-1/2 containing MDA-MB-231 and HT-29 tumor cell lines. The metabolic activity of non-tumorigenic HS-5 cells and COX-1/2-independent MCF-7 cells is not influenced.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/DT/C7DT04790H

Reference31 articles.

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