Two different regimes in alcohol-induced coil–helix transition: effects of 2,2,2-trifluoroethanol on proteins being either independent of or enhanced by solvent structural fluctuations-Reference-Cited by-同舟云学术

Two different regimes in alcohol-induced coil–helix transition: effects of 2,2,2-trifluoroethanol on proteins being either independent of or enhanced by solvent structural fluctuations

Published:2021 Issue:10 Volume:23 Page:5760-5772
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Ohgi Hiroyo¹²³⁴⁵,Imamura Hiroshi⁶⁷⁸⁹⁵^ORCID,Sumi Tomonari¹⁰¹¹¹²⁵^ORCID,Nishikawa Keiko¹²³⁴⁵^ORCID,Koga Yoshikata¹¹³¹⁴¹⁵^ORCID,Westh Peter¹⁶¹⁷¹⁸¹⁹²⁰^ORCID,Morita Takeshi¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Graduate School of Science

3. Chiba University

4. Chiba 263-8522

5. Japan

6. Department of Applied Chemistry

7. College of Life Sciences

8. Ritsumeikan University

9. Shiga 525-8577

10. Research Institute for Interdisciplinary Science

11. Okayama University

12. Okayama 700-8530

13. The University of British Columbia

14. Vancouver

15. Canada

16. Department of Biotechnology and Biomedicine

17. Technical University of Denmark

18. Søltofts Plads

19. Lyngby

20. Denmark

Abstract

Solvent fluctuation (G_TFE-TFE) of 2,2,2-trifluoroethanol (TFE)–H₂O mixture was determined by small-angle X-ray scattering investigation. Protein’s coil–helix transition can be induced by preferential binding of TFE (ΔΓ₂₃) without aggregation of TFE.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D0CP05103A

Reference70 articles.

1. Clustering of Fluorine-Substituted Alcohols as a Factor Responsible for Their Marked Effects on Proteins and Peptides

2. THE SOLUTION PROPERTIES AND CONFIGURATIONS OF A POLYAMPHOLYTIC POLYPEPTIDE: COPOLY-L-LYSINE-L-GLUTAMIC ACID

3. Trifluoroethanol and colleagues: cosolvents come of age. Recent studies with peptides and proteins