DNA topology influences molecular machine lifetime in human serum

Author:

Goltry Sara123,Hallstrom Natalya123,Clark Tyler42352,Kuang Wan623,Lee Jeunghoon12372,Jorcyk Cheryl823,Knowlton William B.12362,Yurke Bernard12362,Hughes William L.123,Graugnard Elton123

Affiliation:

1. Department of Materials Science & Engineering

2. Boise State University

3. Boise, USA

4. Department of Physics

5. Department of Mathematics

6. Department of Electrical & Computer Engineering

7. Department of Chemistry & Biochemistry

8. Department of Biological Sciences

Abstract

Lifetimes and operational performance were investigated for a DNA nanomachine and linear probe in human serum and blood to elucidate design principles for future biomedical applications of DNA-based devices.

Funder

W.M. Keck Foundation

National Institute of General Medical Sciences

National Center for Research Resources

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Reference53 articles.

1. A DNA-fuelled molecular machine made of DNA

2. Nucleic acid-based nanoengineering: novel structures for biomedical applications

3. F. Wang , B.Willner and I.Willner , in Molecular Machines and Motors: Recent Advances and Perspectives , ed. A. Credi , S. Silvi and M. Venturi , Springer International Publishing , 2014 , vol. 354 , ch. 515, pp. 279–338

4. A primer to scaffolded DNA origami

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