Environmentally friendly SPPS I. Application of NaOH in 2-MeTHF/methanol for Fmoc removal-Reference-Cited by-同舟云学术

Environmentally friendly SPPS I. Application of NaOH in 2-MeTHF/methanol for Fmoc removal

Published:2019 Issue:4 Volume:21 Page:775-779
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Přibylka Adam¹²³⁴⁵^ORCID,Krchňák Viktor¹²³⁴⁵^ORCID,Schütznerová Eva¹²³⁴⁵^ORCID

Affiliation:

1. Department of Organic Chemistry

2. Faculty of Science

3. Palacký University

4. 771 46 Olomouc

5. Czech Republic

Abstract

Focusing on the step-by-step transformation of the traditional solid-phase peptide synthesis (SPPS) into an environmentally friendly process, we herein report the elimination of environmentally hazardous components (piperidine, DMF and DCM) from this technique.

Funder

University of Notre Dame

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/GC/C8GC03778G

Reference32 articles.

1. The Future of Peptide-based Drugs

2. Peptide therapeutics: current status and future directions