Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid

Author:

Di Yuanyuan12345,Li Zhongqi6785,Li Jin6785,Cheng Qiangqiang6785,Zheng Qi6785,Zhai Chenyang6785,Kang Mengsi6785,Wei Chunling12345,Lan Jijun9785,Fan Juan6785,Ren Wei12345,Tian Yingfang6785ORCID

Affiliation:

1. Key Laboratory of Modern Teaching Technology

2. Ministry of Education

3. Shaanxi Normal University

4. Xi'an

5. China

6. College of Life Sciences

7. Shaanxi Normal University. Xi'an

8. Shaanxi

9. School of Psychology

Abstract

Maternal FA supplementation at 4 mg kg−1 rescued the development delay, anxiety and core autism-like behaviors, and restored the abnormal synaptic spine morphology and synaptic protein expression in mPFC in the male offspring prenatally exposed to VPA.

Funder

National Natural Science Foundation of China

National Office for Philosophy and Social Sciences

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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