Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid-Reference-Cited by-同舟云学术

Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid

Published:2021 Issue:10 Volume:12 Page:4544-4555
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Di Yuanyuan¹²³⁴⁵,Li Zhongqi⁶⁷⁸⁵,Li Jin⁶⁷⁸⁵,Cheng Qiangqiang⁶⁷⁸⁵,Zheng Qi⁶⁷⁸⁵,Zhai Chenyang⁶⁷⁸⁵,Kang Mengsi⁶⁷⁸⁵,Wei Chunling¹²³⁴⁵,Lan Jijun⁹⁷⁸⁵,Fan Juan⁶⁷⁸⁵,Ren Wei¹²³⁴⁵,Tian Yingfang⁶⁷⁸⁵^ORCID

Affiliation:

1. Key Laboratory of Modern Teaching Technology

2. Ministry of Education

3. Shaanxi Normal University

4. Xi'an

5. China

6. College of Life Sciences

7. Shaanxi Normal University. Xi'an

8. Shaanxi

9. School of Psychology

Abstract

Maternal FA supplementation at 4 mg kg⁻¹ rescued the development delay, anxiety and core autism-like behaviors, and restored the abnormal synaptic spine morphology and synaptic protein expression in mPFC in the male offspring prenatally exposed to VPA.

Funder

National Natural Science Foundation of China

National Office for Philosophy and Social Sciences

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO02926B

Reference40 articles.

1. Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring