Learning the structure–activity relationship (SAR) of the Wittig reaction from genetically-encoded substrates-Reference-Cited by-同舟云学术

Learning the structure–activity relationship (SAR) of the Wittig reaction from genetically-encoded substrates

Published:2021 Issue:42 Volume:12 Page:14301-14308
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yan Kejia¹,Triana Vivian¹,Kalmady Sunil Vasu²,Aku-Dominguez Kwami¹,Memon Sharyar³,Brown Alex¹^ORCID,Greiner Russell²⁴,Derda Ratmir¹^ORCID

Affiliation:

1. Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada

2. Department of Computer Science, University of Alberta, Alberta, AB T6G 2E8, Canada

3. Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada

4. Alberta Machine Intelligence Institute, Alberta, AB T5J 3B1, Canada

Abstract

160 000 peptides displayed on phage were subjected to the Wittig reaction with a biotinylated ylide. Deep-sequencing estimated the conversion rate for each sequence and unveiled the relationship between sequences and the rate of the Wittig reaction.

Funder

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

Alberta Machine Intelligence Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04146K

Reference59 articles.

1. New Methods for the High-Throughput Screening of Enantioselective Catalysts and Biocatalysts

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