Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles-Reference-Cited by-同舟云学术

Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles

Published:2020 Issue:47 Volume:12 Page:23959-23966
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Kulkarni Jayesh A.¹²³⁴⁵^ORCID,Thomson Sarah B.⁴⁵⁶²³^ORCID,Zaifman Josh⁷⁶²³⁸,Leung Jerry⁷⁶²³,Wagner Pamela K.⁴⁵⁶²³,Hill Austin⁴⁵⁶²³,Tam Yuen Yi C.⁷⁶²³⁸,Cullis Pieter R.¹²³⁷⁶^ORCID,Petkau Terri L.⁴⁵⁶²³,Leavitt Blair R.⁴⁵⁶²³^ORCID

Affiliation:

1. NanoMedicines Innovation Network

2. Vancouver

3. Canada

4. Center for Molecular Medicine and Therapeutics

5. Department of Medical Genetics

6. University of British Columbia

7. Department of Biochemistry and Molecular Biology

8. Integrated Nanotherapeutics

Abstract

We show that siRNA encapsulation within a lipid nanoparticle (LNP) can occur in the absence of organic solvent and use these studies to propose a mechanism by which siRNA is entrapped during the LNP formulation process.

Funder

British Columbia Innovation Council

Huntington Society of Canada

Canadian Institutes of Health Research

Networks of Centres of Excellence of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR06816K

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