Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)

Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)–H activation

Published:2017 Issue:6 Volume:8 Page:4565-4570
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tang Jian¹²³⁴⁵,He Yadong¹²³⁴⁵,Chen Hongfei¹²³⁴⁵,Sheng Wangjian¹²³⁴⁵,Wang Huan¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. School of Chemistry and Chemical Engineering

3. Nanjing University

4. Nanjing 210093

5. China

Abstract

Synthesis of cyclic peptides with novel Cβ–Ar crosslinks has been achieved by C(sp³)–H activation, and their biological properties have been evaluated for the first time.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC05530C

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