A new class of 7-deazaguanine agents targeting autoimmune diseases: dramatic reduction of synovial fibroblast IL-6 production from human rheumatoid arthritis patients and improved performance against murine experimental autoimmune encephalomyelitis-Reference-Cited by-同舟云学术

A new class of 7-deazaguanine agents targeting autoimmune diseases: dramatic reduction of synovial fibroblast IL-6 production from human rheumatoid arthritis patients and improved performance against murine experimental autoimmune encephalomyelitis

Published:2024 Issue:5 Volume:15 Page:1556-1564
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Cotter Michelle¹,Quinn Shauna M.²,Fearon Ursula³,Ansboro Sharon³,Rakovic Tatsiana³,Southern John M.¹^ORCID,Kelly Vincent P.²^ORCID,Connon Stephen J.¹^ORCID

Affiliation:

1. School of Chemistry, Trinity College, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin, Ireland

2. School of Biochemistry & Immunology, Trinity College, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin, Ireland

3. School of Medicine, Trinity College, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin, Ireland

Abstract

IL-6 production in treated human synovial fibroblasts from rheumatoid arthritis patients has been utilised to select candidates from a targeted library of queuine tRNA ribosyltransferase (QTRT) substrates for subsequent in vivo screening in murine experimental autoimmune encephalomyelitis.

Funder

Trinity College Dublin

Science Foundation Ireland

Enterprise Ireland

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00028E

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