Temperature and ultrasound sensitive gatekeepers for the controlled release of chemotherapeutic drugs from mesoporous silica nanoparticles

Abstract

The copolymer chains were grafted onto the mesopores of silica nanoparticles and could act as stimuli responsive ‘smart’ gatekeepers. With the aid of a transdermal delivery route and ultrasound penetration, even malignant sites of internal organs can be set as targets.