A continuous flow protocol to generate, regenerate, load, and recycle chlorotrityl functionalised resins-Reference-Cited by-同舟云学术

A continuous flow protocol to generate, regenerate, load, and recycle chlorotrityl functionalised resins

Published:2019 Issue:7 Volume:4 Page:1309-1317
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Spare Lawson K.¹²³⁴^ORCID,Menti Maria¹²³⁴,Harman David G.⁵⁶⁴⁷⁶,Aldrich-Wright Janice R.¹²³⁴⁸^ORCID,Gordon Christopher P.¹²³⁴⁷^ORCID

Affiliation:

1. School of Science and Health

2. Western Sydney University

3. Penrith South DC

4. Australia

5. School of Medicine

6. Western Sydney University, Campbelltown Campus

7. Molecular Medicine Research Group

8. Nanoscale Organisation and Dynamics Group

Abstract

From a screen of chlorinating agent concentration, flow rates, and reagent addition methodologies, a continuous flow protocol to activate, reactivate, and recycle both 2-chlorotrityl chloride functionalised polystyrene and trityl-hydroxy ChemMatrix functionalised resins was established.

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RE/C8RE00318A

Reference39 articles.

1. Accelerated Synthesis of Protected Peptides in a Continuous-Flow Fixed-Bed Reactor

2. Automated Allyl Cleavage for Continuous-Flow Synthesis of Cyclic and Branched Peptides

3. Continuous flow synthesis of peptides using a polyacrylamide gel resin (Expansin™)

4. Continuous-flow solid-phase peptide synthesis

5. Continuous-flow solid-phase peptide synthesis using polystyrene resins

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