Unnatural enzyme activation by a metal-responsive regulatory protein-Reference-Cited by-同舟云学术

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Unnatural enzyme activation by a metal-responsive regulatory protein

Published:2024 Issue:35 Volume:15 Page:14209-14217
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Halfin Olga¹,Avram Liat²^ORCID,Albeck Shira³,Unger Tamar³,Motiei Leila¹,Margulies David¹^ORCID

Affiliation:

1. Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel

2. Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel

3. Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel

Abstract

A bifunctional molecule with binders for calmodulin (CaM) and glutathione S-transferases (GST) converts GST into a triggerable enzyme, whose activity is unnaturally regulated by CaM's conformational state and consequently, by calcium ions.

Funder

Minerva Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02635G

Reference39 articles.

1. Recent Advances in Enzyme Inhibition: A Pharmacological Review

2. DNA Detection and Signal Amplification via an Engineered Allosteric Enzyme

3. An Amplified Assay for Thiols Based on Reactivation of Papain

4. Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

5. Upregulation of an Artificial Zymogen by Proteolysis

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