Targeted nanoparticles from xyloglucan–doxorubicin conjugate loaded with doxorubicin against drug resistance

Author:

Xie Xuan12345,Luo Shiying12345,Mukerabigwi Jean Felix12345,Mei Jian12345,Zhang Yuannian12345,Wang Shufang6789,Xiao Wang12345,Huang Xueying12345,Cao Yu12345

Affiliation:

1. Key Laboratory of Pesticide and Chemical Biology (Ministry of Education)

2. College of Chemistry

3. Central China Normal University

4. Wuhan 430079

5. P. R. China

6. Blood Transfusion Department

7. The General Hospital of the People's Liberation Army

8. Beijing 100853

9. China

Abstract

The novel targeted Xyloglucan–doxorubicin nanoparticle drug delivery systems (DOX nano-DDSs) exhibited improved cellular uptake, increased accumulation in tumor, higher cytotoxicity against drug resistant tumor cells and reduced side effects.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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