Nanogold POxylation: towards always-on fluorescent lung cancer targeting

Author:

Silva A. Sofia12345,Silva Marta C.12345,Miguel Sónia P.678910,Bonifácio Vasco D. B.11121314,Correia Ilídio J.678910ORCID,Aguiar-Ricardo Ana12345ORCID

Affiliation:

1. LAQV-REQUIMTE

2. Departamento de Química

3. Faculdade de Ciências e Tecnologia

4. Universidade Nova de Lisboa

5. Campus de Caparica

6. CICS-UBI

7. Health Sciences Research Center

8. Faculdade de Ciências da Saúde

9. Universidade da Beira Interior

10. 6200-506 Covilhã

11. Centro de Química-Física Molecular and Institute of Nanosciences and Nanotechnology

12. Instituto Superior Técnico

13. 1049-001 Lisboa

14. Portugal

Abstract

Gold nanoparticles (GNPs) were POxylated with fluorescent oligomers, synthesized in supercritical CO2, and conjugated with a laminin fragment. Particle design strongly impacts on probes uptake by the A549 cell line.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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