Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues-Reference-Cited by-同舟云学术

Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues

Published:2021 Issue:83 Volume:57 Page:10923-10926
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Dowman Luke J.¹²^ORCID,Agten Stijn M.¹^ORCID,Ripoll-Rozada Jorge³⁴^ORCID,Calisto Bárbara M.⁵^ORCID,Pereira Pedro José Barbosa³⁴^ORCID,Payne Richard J.¹²^ORCID

Affiliation:

1. School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia

2. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydne, NSW 2006, Australia

3. IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal

4. Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal

5. ALBA Synchrotron, 08290 Cerdanyola del Vallès, Spain

Abstract

We describe the incorporation of two acid-stable mimics of sulfotyrosine into thrombin-inhibiting peptides and assess their activity and binding mode.

Funder

National Health and Medical Research Council

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC04742F

Reference30 articles.

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4. Tyrosine sulfation is a trans-Golgi-specific protein modification.

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