Catalyst-free dehydrative SN1-type reaction of indolyl alcohols with diverse nucleophiles “on water”-Reference-Cited by-同舟云学术

Catalyst-free dehydrative SN1-type reaction of indolyl alcohols with diverse nucleophiles “on water”

Published:2016 Issue:4 Volume:18 Page:1032-1037
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Xiao Jian¹²³⁴,Wen Hao⁵⁶⁷⁸⁹,Wang Liang¹²³⁴,Xu Lubin¹²³⁴,Hao Zhihui¹²³⁴,Shao Chang-Lun⁵⁶⁷⁸⁹,Wang Chang-Yun⁵⁶⁷⁸⁹

Affiliation:

1. College of Chemistry and Pharmaceutical Sciences

2. Qingdao Agricultural University

3. Qingdao

4. China

5. Key Laboratory of Marine Drugs

6. The Ministry of Education of China

7. School of Medicine and Pharmacy

8. Ocean University of China

9. Qingdao 266003

Abstract

An efficient dehydrative S_N1-type reaction of indolyl alcohols with diverse nucleophiles was developed using water as the solvent, affording versatile 3-indolyl derivatives in high yields. The advantages of being catalyst-free, environmentally benign, and wide substrate scope make it a promising method for preparation of indolyl compounds.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/GC/C5GC01838B

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