Targeted killing of tumor cells based on isoelectric point suitable nanoceria-rod with high oxygen vacancies

Author:

Ma Baofu12,Han Jianyu32,Zhang Kun14,Jiang Qike5,Sui Zhigang1,Zhang Zhixin3ORCID,Zhao Baofeng124ORCID,Liang Zhen1,Zhang Lihua1,Zhang Yukui1

Affiliation:

1. CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China

2. University of Chinese Academy of Sciences, Beijing 100039, China

3. State Key Laboratory of Catalysis, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

4. The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, Liaoning Province 110001, China

5. Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Abstract

Highly active nanoceria-rod with suitable IEP could selectively target tumor cells and enter the lysosomes and phagosomes of tumor cells to produce ROS, causing cell apoptosis.

Funder

National Natural Science Foundation of China

Dalian Institute of Chemical Physics

Liaoning Revitalization Talents Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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