A hydrolyzed casein diet promotes Ngn3 controlling enteroendocrine cell differentiation to increase gastrointestinal motility in mice

Author:

Liu Siqiang12ORCID,Zhu Haining12,Ren Yuting12,Fan Wenlu12,Wu Haiqin12,Wu Huipeng12,Huang Zan12ORCID,Zhu Weiyun12ORCID

Affiliation:

1. Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China

2. National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural, University, Nanjing, Jiangsu 210095, China

Abstract

Feeding hydrolyzed casein as the solo protein source to mice increased serum ghrelin levels and duodenal X/A cell numbers, possibly by influencing the abundance of A. muciniphila, thereby modulating Ngn3 to control EEC differentiation.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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