Replacement of oxygen with sulfur on the furanose ring of cyclic dinucleotides enhances the immunostimulatory effect via STING activation-Reference-Cited by-同舟云学术

Replacement of oxygen with sulfur on the furanose ring of cyclic dinucleotides enhances the immunostimulatory effect via STING activation

Author:

Saito–Tarashima Noriko¹^ORCID,Kinoshita Mao¹,Igata Yosuke¹,Kashiwabara Yuta¹,Minakawa Noriaki¹

Affiliation:

1. Graduate School of Pharmaceutical Science, Tokushima University, Shomachi 1-78-1, Tokushima 770-8505, Japan

Abstract

Cyclic dinucleotide analogues that have sulfur atoms on the furanose rings act as potent and stable STING agonists.

Funder

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Tokyo Biochemical Research Foundation

Naito Foundation

Takeda Science Foundation

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

Reference46 articles.

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5. Chemistry of Cyclic Dinucleotides and Analogs;Handbook of Chemical Biology of Nucleic Acids;2023