Asymmetric synthesis of γ-aryl-substituted GABA derivatives via a highly diastereoselective Rh-catalyzed boronic acid addition at room temperature-Reference-Cited by-同舟云学术

Asymmetric synthesis of γ-aryl-substituted GABA derivatives via a highly diastereoselective Rh-catalyzed boronic acid addition at room temperature

Published:2015 Issue:8 Volume:2 Page:885-889
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Ramachandran P. Veeraraghavan¹²³⁴⁵,Mitsuhashi Wataru¹²³⁴⁵,Biswas Bidyut¹²³⁴⁵

Affiliation:

1. Herbert C. Brown Center for Borane Research

2. Department of Chemistry

3. Purdue University

4. 560 Oval Dr. West Lafayette

5. USA

Abstract

A highly diastereoselective Rh-catalyzed boronic acid addition to enantiopure sulfinylimines at room temperature providing γ-aryl GABA derivatives has been described.

Funder

Herbert C. Brown Center for Borane Research, Purdue University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/QO/C5QO00133A

Reference24 articles.

1. Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

2. For a special focus issue on GABAergic drugs, seeFuture Med. Chem., 2011, 3, 139

3. A Role of GABA Analogues in the Treatment of Neurological Diseases

4. Stereoselective synthesis of γ-amino acids

5. An Update on GABA Analogs for CNS Drug Discovery

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