Enhanced anti-tumor activity of a drug through pH-triggered release and dual targeting by calcium phosphate-covered mesoporous silica vehicles

Author:

Liu Juan12,Hu Xixue3,Jin Shubin4,Liang Xing-Jie3ORCID,Ma Xiaowei1ORCID

Affiliation:

1. National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

2. Hepato-Pancreato-Biliary Center, Translational Research Center, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing, China

3. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing, 100190, China

4. Beijing Municipal Institute of Labour Protection No. 55 Taoranting Road, Xicheng District, Beijing 100054, P. R. China

Abstract

Mesoporous silica nanoparticles coated with poly(N-isopropylacrylamide)-co-acrylic acid and calcium phosphate (MSCN) and decorated with transferrin (Tf)/RGD ligands on the surface exhibited various functions.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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