Unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin-Reference-Cited by-同舟云学术

Unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin

Published:2017 Issue:30 Volume:15 Page:6401-6410
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hajra Saumen¹²³⁴⁵^ORCID,Acharyya Susit¹²³⁴⁵,Mandal Abhisek⁶⁷⁸⁵,Maity Ramkrishna¹²³⁴⁵

Affiliation:

1. Molecular Synthesis & Drug Discovery Laboratory

2. Centre of Biomedical Research (CBMR)

3. Sanjay Gandhi Post-Graduate Institute of Medical Sciences (SGPGIMS) Campus

4. Lucknow 226014

5. India

6. Department of Chemistry

7. Indian Institute of Technology (IIT) Kharagpur

8. Kharagpur 721302

Abstract

The combination of stereocontrolled Evans syn-aldol, intramolecular ene and RCM reactions is shown to be a general protocol for the synthesis of C8-deoxy- and -oxy guaianolides. Unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin is demonstrated from a common precursor.

Funder

Council for Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01217A

Reference39 articles.

1. Synthesis and Biological Activity of ?-Methylene-?-butyrolactones

2. Lactones: Generic Inhibitors of Enzymes?

3. What made sesquiterpene lactones reach cancer clinical trials?