Platinum complexes as inhibitors of DNA repair protein Ku70 and topoisomerase IIα in cancer cells-Reference-Cited by-同舟云学术

Platinum complexes as inhibitors of DNA repair protein Ku70 and topoisomerase IIα in cancer cells

Published:2022 Issue:8 Volume:51 Page:3188-3197
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Zhang Hongmei¹²,Wang Ying¹,Wang Yanqing²,Han Qianqian²,Yan Honghao²,Yang Tao¹,Guo Zijian³⁴^ORCID,Wang Xiaoyong¹⁴^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China

2. School of Chemical and Environmental Engineering, Yancheng Teachers University, Yancheng, Jiangsu Province 224007, P. R. China

3. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China

4. Nanchuang (Jiangsu) Institute of Chemistry and Health, Jiangbei New Area, Nanjing 210000, P. R. China

Abstract

Ku70 and Topo IIα are hopeful targets of anticancer drugs. Platinum complex OPPC shows high antiproliferative activity towards cancer cells, which is associated with the damage to DNA, downregulation of Ku70, and inhibition of Topo IIα.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D1DT03700E

Reference53 articles.

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