Structural elucidation and synthesis of a dimeric degradation impurity during long-term stability studies of oxycodone hydrochloride injection-Reference-Cited by-同舟云学术

Structural elucidation and synthesis of a dimeric degradation impurity during long-term stability studies of oxycodone hydrochloride injection

Published:2021 Issue:39 Volume:45 Page:18651-18658
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zhuang Tao¹²,Jin Jian²,Ma Yurong²,Ren Xia²,Liang Lingzhi²,Du Wei¹^ORCID,Liu Bifeng¹^ORCID,Liu Xin¹^ORCID,Zhang Guisen¹²^ORCID

Affiliation:

1. Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

2. Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China

Abstract

An unknown degradation product (impurity-I) observed in oxycodone hydrochloride injection was proposed as an oxycodone aldol dimer using 2D LC-QTOF MS/MS, and impurity-I was synthesized and verified by 1D-NMR and 2D-NMR spectroscopy techniques.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ03344A

Reference20 articles.

1. Breaking barriers to novel analgesic drug development

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