Stability and anti-inflammatory activity of the reduction-resistant curcumin analog, 2,6-dimethyl-curcumin-Reference-Cited by-同舟云学术

Stability and anti-inflammatory activity of the reduction-resistant curcumin analog, 2,6-dimethyl-curcumin

Published:2018 Issue:17 Volume:16 Page:3273-3281
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Joseph Akil I.¹²³⁴⁵,Edwards Rebecca L.¹²³⁴⁵,Luis Paula B.¹²³⁴⁵,Presley Sai Han¹²³⁴⁵,Porter Ned A.⁶³⁷⁵⁸,Schneider Claus¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacology

2. Division of Clinical Pharmacology

3. and Vanderbilt Institute of Chemical Biology

4. Vanderbilt University School of Medicine

5. Nashville

6. Department of Chemistry

7. Vanderbilt University

8. USA

Abstract

Degradation products are linked to anti-inflammatory activity of 2,6-dimethyl-curcumin, a synthetic analog of curcumin stable against metabolic reduction in vivo.

Funder

National Center for Complementary and Integrative Health

National Institute of Environmental Health Sciences

American Heart Association

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00639C

Reference44 articles.

1. Curcumin-From Molecule to Biological Function

2. The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

3. Turmeric Extracts Containing Curcuminoids Prevent Experimental Rheumatoid Arthritis

4. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

5. Curcumin Down-Regulates DNA Methyltransferase 1 and Plays an Anti-Leukemic Role in Acute Myeloid Leukemia

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