Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip-Reference-Cited by-同舟云学术

Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip

Published:2016 Issue:10 Volume:8 Page:1022-1029
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Li Zhongyu¹²³⁴⁵,Guo Yaqiong¹²³⁴⁵,Yu Yue¹²³⁴⁵,Xu Cong¹²³⁴⁵,Xu Hui¹²³⁴⁵,Qin Jianhua¹²³⁴

Affiliation:

1. Division of Biotechnology

2. Dalian Institute of Chemical Physics

3. Chinese Academy of Sciences

4. China

5. University of Chinese Academy of Sciences

Abstract

This work presents a new and multifunctional organs-on-a-chip device that allows for the characterization of the multi-step metabolism processes of pro-drug CAP in liver cells and its resultant efficacy in multiple target cells simultaneously and quantitatively.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2016/IB/C6IB00162A

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