Design and development of plastic antibodies against SARS-CoV-2 RBD based on molecularly imprinted polymers that inhibit in vitro virus infection-Reference-Cited by-同舟云学术

Design and development of plastic antibodies against SARS-CoV-2 RBD based on molecularly imprinted polymers that inhibit in vitro virus infection

Published:2021 Issue:40 Volume:13 Page:16885-16899
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Parisi Ortensia Ilaria¹²,Dattilo Marco¹,Patitucci Francesco¹,Malivindi Rocco¹²,Delbue Serena³,Ferrante Pasquale³,Parapini Silvia⁴,Galeazzi Roberta⁵,Cavarelli Mariangela⁶,Cilurzo Francesco⁷,Franzè Silvia⁷,Perrotta Ida⁸,Pezzi Vincenzo¹²,Selmin Francesca⁷,Ruffo Mariarosa¹²,Puoci Francesco¹²^ORCID

Affiliation:

1. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy

2. Macrofarm s.r.l., c/o Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy

3. Department of Biomedical, Surgical and Dental Sciences, Laboratory of Translational Research, University of Milan, 20133 Milano, Italy

4. Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy

5. Department of Life and Environmental Sciences, Marche Polytechnic University, 60131 Ancona, Italy

6. Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France

7. Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy

8. Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, CS, Italy

Abstract

Molecularly Imprinted Synthetic Material Antibodies (MISMAs) capable of significantly inhibiting SARS-CoV-2 replication in Vero cell culture were developed.

Funder

Università della Calabria

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR03727G

Reference52 articles.

1. A pneumonia outbreak associated with a new coronavirus of probable bat origin

2. World Health Organization, WHO Coronavirus (COVID-19) Dashboard, https://covid19.who.int