Lessons from the Synthetic Chemist Nature-Reference-Cited by-同舟云学术

Lessons from the Synthetic Chemist Nature

Published:2015 Issue:5 Volume:32 Page:723-737
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Jürjens Gerrit¹²³⁴,Kirschning Andreas¹²³⁴,Candito David A.¹²³⁴

Affiliation:

1. Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ)

2. Leibniz Universität Hannover

3. D-30167 Hannover

4. Germany

Abstract

Nature's strategy of performing ideal multistep (bio)synthesis are based on multicatalysis, domino reactions, iteration and compartmentation. These are discussed and compared with chemical synthesis in this conceptual review.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NP/C4NP00160E

Reference83 articles.

1. Systematic synthesis design. IV. Numerical codification of construction reactions

2. The Atom Economy—A Search for Synthetic Efficiency

3. New reactions and step economy: the total synthesis of (±)-salsolene oxide based on the type II transition metal-catalyzed intramolecular [4+4] cycloaddition

4. Function-Oriented Synthesis, Step Economy, and Drug Design

5. Synthesis at the molecular frontier

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