Autophagy inhibitors 3-MA and LY294002 repress osteoclastogenesis and titanium particle-stimulated osteolysis-Reference-Cited by-同舟云学术

Autophagy inhibitors 3-MA and LY294002 repress osteoclastogenesis and titanium particle-stimulated osteolysis

Published:2021 Issue:14 Volume:9 Page:4922-4935
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Chen Weishen¹²³⁴⁵^ORCID,Xian Guoyan¹²³⁴⁵^ORCID,Gu Minghui¹²³⁴⁵,Pan Baiqi¹²³⁴⁵,Wu Xiaoyu¹²³⁴⁵,Ye Yongyu¹²³⁴⁵,Zheng Linli¹²³⁴⁵,Zhang Ziji¹²³⁴⁵,Sheng Puyi¹²³⁴⁵^ORCID

Affiliation:

1. Department of Joint Surgery

2. The First Affiliated Hospital of Sun Yat-Sen University

3. Guangzhou 510080

4. China

5. Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology

Abstract

In this study, we found autophagy inhibitors 3-MA and LY294002 reduced osteoclast differentiation and osteoclast-related genes in vitro. In vivo, 3-MA and LY294002 repressed titanium particle-stimulated inflammatory osteolysis and osteoclastogenesis.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00691F

Reference50 articles.

1. The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study

2. Why Are Total Knee Arthroplasties Failing Today—Has Anything Changed After 10 Years?