Synthesis and antibacterial activity evaluation of C-5 side chain modified analogues of FYL-66, a potential agent against methicillin-resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Synthesis and antibacterial activity evaluation of C-5 side chain modified analogues of FYL-66, a potential agent against methicillin-resistant Staphylococcus aureus

Published:2015 Issue:6 Volume:6 Page:1156-1172
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Yang Xiaoyan¹²³⁴⁵,Li Zicheng¹²³⁴⁵,Wang Zhenling⁶⁷⁸³⁴,Sang Zitai⁶⁷⁸³⁴,Long Haiyue⁶⁷⁸³⁴,Tang Jianying⁶⁷⁸³⁴,Yang Tao⁶⁷⁸³⁴,Liu Yuanyuan⁶⁷⁸³⁴,Luo Youfu⁶⁷⁸³⁴

Affiliation:

1. Department of Pharmaceutical and Bioengineering

2. School of Chemical Engineering

3. Sichuan University

4. Chengdu

5. PR China

6. State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy

7. West China Hospital

8. West China Medical School

Abstract

Monofluoro- (39), difluoro- (40) and trifluoro- (41) substituted analogues showed different biological activities, and 40 is a potent antibacterial agent in animal models.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00101C

Reference36 articles.

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2. Interaction between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA)

3. In Vitro Antimicrobial Activity of Aminoreductone against the Pathogenic Bacteria Methicillin-Resistant Staphylococcus aureus (MRSA)

4. Linezolid (ZYVOX), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections

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