Effect of dibucaine hydrochloride on raft-like lipid domains in model membrane systems-Reference-Cited by-同舟云学术

Effect of dibucaine hydrochloride on raft-like lipid domains in model membrane systems

Published:2015 Issue:8 Volume:6 Page:1444-1451
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Yoshida Kazunari¹²³⁴⁵,Takashima Akito⁶⁷⁸⁹¹⁰,Nishio Izumi⁶⁷⁸⁹¹⁰

Affiliation:

1. New Industry Creation Hatchery Center

2. Tohoku University

3. 6-6-10 Aoba

4. Aoba-ku

5. Japan

6. Department of Physics and Mathematics

7. College of Science and Engineering

8. Aoyama Gakuin University

9. 5-10-1 Fuchinobe

10. Sagamihara

Abstract

To clarify the biophysical and/or physicochemical mechanism of anaesthesia, we investigated the influence of dibucaine hydrochloride (DC·HCl), a local anaesthetic, on raft-like domains in ternary liposomes composed of dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC) and cholesterol (Chol).

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00108K

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